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ANTISENSE COMPOSITIONS WITH ENTERIC COATING FOR TREATING CROHN'S DISEASE, COLITIS AND BOWEL DISEASE
ANTISENSE COMPOSITIONS WITH ENTERIC COATING FOR TREATING CROHN'S DISEASE, COLITIS AND BOWEL DISEASE
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机译:具有肠溶衣的抗感组合物,可治疗克罗恩病,结肠炎和肠病
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摘要
592673 Provided is a pharmaceutical tablet formulation for oral administration of an antisense oligonucleotide comprising: an intra-granular phase comprising a specified antisense oligonucleotide designed to inhibit SMAD7 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable filler; an extra-granular phase comprising a disintegrant; and an enteric coating comprising an ethylacrylate-methacrylic acid copolymer. The composition can be used to treat Crohn's disease, ulcerative colitis and inflammatory bowel disease.
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