SUBSTITUTED PYRAZOLOPYRIMIDINES AND THE USE THEREOF IN THE TREATMENT OF CHRONIC NEURODEGENERATIVE DISEASE AND NEUROTRAUMATIC DISEASE

摘要

595506 Disclosed herein is a compound of Formula (I), wherein the variables are defined in the specification, and the use thereof in the treatment of a chronic neurodegenerative disease such as Alzheimer's Disease, Parkinson's Disease, progressive supranuclear palsy, subacute panencephalitic parkinsonism, postencephalitic parkinsonism, dementia puglistica, guan-parkinsonial dementia complex, Pick's disease, corticobasal degeneration, frontotemporal dementia with parkinsonism, Huntington's disease, AIDS associated dementia, amyotrophic lateral sclerosis, and multiple sclerosis, or a neurotraumatic disease, such as acute stroke, mood disorders such as schizophrenia and bipolar disorders, promotion of functional recovery post stroke, cerebral bleeding, hair loss, obesity, atherosclerotic cardiovascular disease, hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, cancer, leukopenia, Down's syndrome, Lewy body disease, inflammation and immunodeficiency. Exemplary compounds include: 3-(6-chloro-2-cyclopentyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)-2-oxo-2,3-dihydro-1H-indole-5-carbonitrile; 3-{ 6-[bis-(2-methoxyethyl)amino]-2-cyclopentyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl} -2-oxo-2,3-dihydro-1H-indole-5-carbonitrile; 2-oxo-3-[2-propyl-6-(2-pyridin-2-yl-ethylamino)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-2,3-dihydro-1H-indole-5-carbonitrile; and 5-chloro-3-[2-cyclopentyl-6-((R)-2-hydroxy-propylamino)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-1,3-dihydro-indol-2-one.