Parenteral Pharmaceutical Form, which releases progestin and aromatase inhibitors for the treatment of endometrosis

摘要

Refers to a Pharmaceutical composition comprising: (a) an aromatase inhibitor in a dose equivalent to the exposure of anastrozole after oral administration at a dose of 1 mg, or between 0.1 and 0.9 mg anastrozole mg per day, Selected among anastrozole, exemestane, Fadrozole, Formestane, letrozole, pentrozol,Vorozole among others; (b) A progestin at a dose equivalent to the exposure of levonorgestrel after oral administration at a dose of more than 10? G, but less than 50? G per day, Selected among men, gestodene, treatment, among others. The pharmaceutical composition is selected from Intrauterine device, intravaginal ring, among others.The composition provides a controlled release of active Principles and is useful in the treatment of endometriosis.