首页> 外国专利> A pharmaceutical dosage form comprising 6 '- fluoro - (N - methyl - n, N - dimethyl - 2 - phenyl) - 4, 4' - phenyl Dihydro 3, 9 '-' H - 1,1 '- ciclohexan Spiro pyrano 3,4 - 4, b indole amine

A pharmaceutical dosage form comprising 6 '- fluoro - (N - methyl - n, N - dimethyl - 2 - phenyl) - 4, 4' - phenyl Dihydro 3, 9 '-' H - 1,1 '- ciclohexan Spiro pyrano 3,4 - 4, b indole amine

机译:包含6'-氟-(N-甲基-n,N-二甲基-2-苯基)-4,4'-苯基二氢3,9'-'H-[1,1'-环己基Spiro pyrano的药物剂型[3,4]-4,b]吲哚胺

摘要

Referring to a pharmaceutical dosage form for oral administration comprising a polymeric Matrix material which is dispersed in the Solid Active Agent of formula (i), wherein R is H or CH3 and the polymer is Copolymer of vinylpyrrolidone - polyvinylpyrrolidone, Polyvinyl Acetate, Cellulose Derivatives, among others.Also includes a Surfactant selected from polyoxyethylene Fatty Acid esters, esters of Fatty Acid esters and partial polioxietilensorbitan sulfuric acid.Favorites: compounds are (1R, 4R) - 6 '- fluoro - n, N - dimethyl - 2 - phenyl - 4' 9 ', 3' - dihydro - H - [1,1 '- ciclohexan Spiro pyrano [3,4] - 4, b] indole Amine, (1R, 4R) - 6' - fluoro - N - methyl - 4 - phenyl - 4 '9', 3 '- dihydro - H - [1,1' - ciclohexan Spiro pyrano [3,4] - 4, b] indole Amine or a Salt thereof. The dosage form is useful in the treatment of acute pain, Chronic neuropathic and visceral
机译:指用于口服的药物剂型,其包含分散在式(i)的固体活性剂中的聚合物基体材料,其中R是H或CH 3,并且该聚合物是乙烯基吡咯烷酮-聚乙烯吡咯烷酮,乙酸乙烯酯,纤维素衍生物的共聚物,还包括选自聚氧乙烯脂肪酸酯,脂肪酸酯和部分多氧杂环戊烷硫酸的表面活性剂最喜欢的化合物是(1R,4R)-6'-氟-n,N-二甲基-2-苯基- 4'9',3'-二氢-H-[1,1'-环己基螺吡喃[3,4]-4,b]吲哚胺,(1R,4R)-6'-氟-N-甲基-4 -苯基-4′9′,3′-二氢-H- [1,1′-环己基螺吡喃并[3,4] -4,b]吲哚胺或其盐。该剂型可用于治疗急性疼痛,慢性神经病和内脏

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