Anti n3pglu β - ameluyd cucumber antibody and its application

摘要

It relates to a monoclonal alpha beta anti-n3pglu antibody designed by genetic engineering and a part of the variable region composed of a carbamate sequence: a) sec ID n ° 3, section ID n ° 45, light chain R1 (LCDR1); b) sec ID n ° 4, section ID n ° 35, light chain R2 (LCDR2). (c) R3 (LCDR3) light chain in SEC ID No. 5; (d) R1 (HCDR1) heavy chain in SEC n ° 6, ID n ° 7, ID n ° 40; (E) R2 (HCDR2) heavy chain in SEC n ° 8; (f) R3 (HCDR3) heavy chain in SEC r r n ° 9, ID n ° 10, section 41, ID n ° 46. Except for a pharmaceutical composer This antibody is useful in the treatment of Alzheimer's disease.