6-METHYL-4-PHENYL-5-(PHENYL OR CYCLOALKYL)CARBAMOYL-1,2,3,4-TETRAHYDROPYRIMIDIN-2-ONE DERIVATIVES AS ANTITUBERCULAR AGENTS

摘要

The present invention discloses antitubercular compounds selected from tetrahydropyrimidones/ tetrahydrothiopyrimidone derivatives of Formula (1) and its pharmaceutically acceptable salts for the treatment of Mycobacterium in the dormant phase. Formula (1) wherein, R is H, halogen, dihalogen, O-alkyl, di- O-alkyl, R1 is phenyl, chlorophenyl, nitrophenyl, diclorophenyl, cycloalkyl, preferably cyclohexyl, X is O or S.