CONTROLLABLE ASSEMBLY AND DISASSEMBLY OF NANOPARTICLE SYSTEMS VIA PROTEIN AND DNA AGENTS

摘要

ABSTRACTCONTROLLABLE ASSEMBLY AND DISASSEMBLY OF NANOPARTICLE SYSTEMS VIA PROTEIN AND DNA AGENTSThe invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three- dimensional DNA binding protein-mediated nanoparticle structures and the resulting structures are described. Specifically embodied is the use of the gene 5 protein (g5p). Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.Figure 2