Chiral compounds containing a nucleus substituted 1,2-imidazo-4,5-c condensate

摘要

A compound of Formula II or IV wherein: X is a bond X 'is a C1 alkylene. Z is selected from the group consisting of -O- and -N (-Y-R2) -; R1 is selected from the group consisting of: - X1-Y-R4, -X1-Y-X '' - Y1-R4, and -X 1 -R 5; X1 is selected from the group consisting of alkylene and alkenylene, wherein the alkylene and alkenylene are optionally interrupted by one or more -O- groups and optionally substituted by a hydroxy or methoxy group; X "is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, heteroarylene, and heterocyclylene wherein the alkylene, alkenylene and alkynylene groups can be optionally interrupted or terminated by arylene, heteroarylene or heterocyclylene and optionally interrupted by one or more -O- groups; Y is selected from the group consisting of: a bond, -S (O) 2-, -S (O) 2-N (R8) -, -C (R6) -, -C ( R6) -N (R8) -, -C (R6) -N (R8) -C (R6) -, -C (R6) -N (R8) -S (O) 2- and -C (R6) - O-; Y 'is selected from the group consisting of: - O-, -S (O) 0-2-, -S (O) 2-N (R8) -, -C (R6) -, -C (R6) -O-, -OC (R6) -, -OC (O) -O-, -N (R8) -Q-, -C (R6) -N (R8) -, -OC (R6) - N (R8) -, -C (R6) -N (OR9) -, -ON (R8) -Q-, -ON = C (R4) -, -C ( = NOR 8) -, -CH (-N (-O-R8) -Q-R4) -, or substituted with one or more substituents independently selected from the group consisting of alkyl, alkoxy, alkylthio, alkanoyl, alkanoyloxy, alkoxycarbonyl, hydroxyalkyl; haloalkyl; haloalkoxy; halogen; nitro; hydroxy; mercapto; cyano; aryl; aryloxy; arylthio; arylalkyleneoxy; heteroaryl; heteroaryloxy; heteroarylalkyleneoxy; heterocyclyl; Not me; alkylamino; dialkylamino; (Dialkylamino) alkyleneoxy; in the case of alkyl, alkenyl, alkynyl, and heterocyclyl, oxo; and, in the case of aryl, methylenedioxy; R4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl wherein the alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl may be unsubstituted or substituted with one or more substituents independently selected from the group consisting of alkyl; alkoxy; hydroxyalkyl; haloalkyl; haloalkoxy; halogen; nitro; hydroxy; mercapto; cyano; aryl; aryloxy; arylalkyleneoxy; heteroaryl; heteroaryloxy; heteroarylalkyleneoxy; heterocyclyl; Not me; alkylamino; dialkylamino; (Dialkylamino) alkyleneoxy; and, in the case of alkyl, alkenyl, alkynyl and heterocyclyl, oxo; R5 is selected from the group consisting of: 25 R6 is selected from the group consisting of = O and = S; 30 R7 is C 2-7 alkylene; R8 is selected from the group consisting of hydrogen, C1-10 alkyl, C2-10 alkenyl, C1-10 hydroxy-alkylenyl, C1-10 alkoxy C1-10 alkylenyl, aryl, and heteroaryl C1-10 alkylenyl alkylenyl C1- 10; R9 is selected from the group consisting of hydrogen and alkyl; R10 is C3-8 alkylene; A is selected from the group consisting of-CH2-, -O-, -C (O) -, -S (O) 0-2-, and -N (-Q-R4) -; A 'is selected from the group consisting of-O-, -S (O) 0-2-, -N (-Q-R4) -and -CH2-; Q is selected from the group consisting of a bond, -C (R6) -, -C (R6) -C (R6) -, -S (O) 2-, -C (R6) -N (R8) - W-, -S (O) 2-N (R8) -, -C (R6) -O-, -C (R6) -S-, and -C (R6) -N (OR9) -; V is selected from the group consisting of-C (R6) -, -OC (R6) -, -N (R8) -C (R6) - and -S (O) 2-; W is selected from the group consisting of a bond, -C (O) - and -S (O) 2-; b are independently integers from 1 to 6 with the proviso that a + b is 7; with the proviso that X 1 can also be a bond when: 20Y 'is bonded to X 1 and Y' is -C (R6) -, -C (R6) -O-, -C (R6) -N (R8) - , -C (R6) -N (OR9) -, -C ( = NOR 8) -, -CH (-N (-O-R8) -Q-R4) -, wherein V is -C ( R6) -, or R5 is bonded to X) and R5 is wherein V is -C (R6) - oo a pharmaceutically acceptable salt thereof, wherein the terms "alkyl", "alkenyl", "alkynyl" and the prefix "alk.", unless otherwise indicated, they include groups of straight and branched chain, and cyclic groups, and these groups contain from 1 to 20 carbon atoms, containing alkynyl alkenyl groups of 2 to 20 carbon atoms carbon.