Procedure prevention of virus cell fusion inhibiting the function of the fusion initiation region of RNA viruses that have envelope proteins fusogenic membrane class I

摘要

A peptide inhibitor of viral fusion isolated selected from the group consisting of: a) a peptide having an amino acid sequence consisting of SEQ ID No. 1, b) a peptide having an amino acid sequence consisting of 8 or more contiguous amino acid residues of SEQ ID NO: 1, c) a peptide analog having an amino acid sequence consisting of SEQ ID No. 1 comprising one or more conservative amino acid substitutions and in most analog residues are identical to those of the sequence of SEQ ID NO: 1, d) a peptide analogue having an amino acid sequence consisting of 8 or more contiguous amino acid residues of SEQ ID 1 including a or more conservative amino acid substitutions and in which most residues are identical to the analogous sequence of 8 or more contiguous amino acid residues of SEQ ID 1, for use in treating a infection arenaviral.