Cells genetically engineered from metabolically for producing resveratrol or an oligomeric derivative thereof or glycosidic linkage

摘要

A microorganism producing resveratrol, and said microorganism having an operative metabolic pathway queproduce 4-coumaric and producing resveratrol from his, or an oligomeric or glicosídicadel binding derivative thereof, whose path 4-coumaric acid is produced from L -phenylalanine by the action of an L-fenilalaninaamoniaco lyase and 4-hydroxylase cinnamate expressed in said microorganism, or from tyrosine by phenylalanine acciónde an L-lyase or a tyrosine ammonia lyase expressed in said microorganism ammonia, 4-coumaroyl seforma -CoA from said coumaric acid in a reaction catalysed by a 4-coumarate-CoA ligasaexpresada in said microorganism, and resveratrol is produced from 4-coumaroyl said-CoA in a reaction in which endogenous malonyl-CoA is unsustrato by resveratrol synthase expressed in said microorganism.