Histone deacetylase inhibitors with combined activity on class I histone deacetylases and Class IIB in combination with proteasome inhibitors

摘要

Combination of a proteasome inhibitor, wherein said proteasome inhibitor is bortezomib, and uninhibidor histone deacetylase, wherein said histone deacetylase inhibitor is compound No. 1a (JNJ26481585) the addition salts of pharmaceutically acid or base acceptable forms and stereochemically isoméricasdel same.