Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory and ischemic remodeling

摘要

Compounds of general formula (I) ** ** Formula wherein A represents a phenyl or pyridyl ring, R1, R2 and R3 independently represent each hydrogen, halogen, nitro, cyano, C1-C6 alkyl, hydroxy oalcoxi-C1-C6 alkyl, wherein the C1-C6 alkoxy-C1-C6 alkyl may be further substituted with one to three radicalesidénticos or different selected from the group consisting of halogen, hydroxy and alkoxy-C1-C4, R4 represents trifluoromethylcarbonyl, alkylcarbonyl-C1-C6 alkoxycarbonyl-C1-C6 alkyl, C1-C6-alkenoxycarbonyl, hydroxycarbonyl, aminocarbonyl, mono- or di-alkylaminocarbonyl-C1-C4, arylaminocarbonyl-C6-C10 arylcarbonyl, heteroarilocarbonilo, heterocyclylcarbonyl, heteroaryl, heterocyclyl or cyano, wherein the alkylcarbonyl-C1-C6 alkyl, C1-C6-elalcoxicarbonilo, the mono- and di-alkylaminocarbonyl-C1-C4 may be further substituted with one to tresradicales identical or different selected from the group consisting of cycloalkyl-C3 8 -cycloalkyl, hydroxy, alkoxy-C1 C4, alkoxycarbonyl-C1-C4 alkyl, hydroxycarbonyl, aminocarbonyl, mono- and di-alkylaminocarbonyl-C1-C4, alkylcarbonylamino-C1-C4 alkyl, (alkylcarbonyl-C1-C4) alkylamino-C1-C4 alkyl, cyano, amino, mono- and dialkylamino-C1-C4 alkyl, heteroaryl, heterocyclyl ytri- (alkyl C1-C6) alkylsilyl and in which the heteroarilocarbonilo, the heterocyclylcarbonyl, heteroaryl and heterociclilopueden further substituted with C1-C4, R5 represents alkyl -C1-C4, which may be substituted with one to three identical or different radicals seleccionadodel group consisting of halogen, hydroxy, C1-C6 alkoxy, alkenoxy-C1-C6 alkylthio-C1-C6-, amino, mono- and dialkylamino-C1-C6 alkyl, arylamino, hydroxycarbonyl, alkoxycarbonyl-C1-C6 and the radical -O-C1-C4 alkyl-O-C1-C4.