Using crystalline mesoporous silica based for locking and controlled release of drugs and pharmaceutical composition comprising the same materials

摘要

Use of a material mesoporous silica substantially ordered for immediate release of poorly soluble unfármaco, wherein said material mesoporous silica substantially ordered esSBA-15 having a mesostructure honeycomb hexagonal bee in two dimensions (P6mm), highly ordered, has spaces d (100) of 7.45 to 45 nm, has a wall thickness of 3.1 to 6.4 nm, quetras calcination at 500 ° C has a BET surface area of ​​690-1040 m2 / g, pore volumes of hasta2,5 cm3 / g and have a pore size in the range of 6 nm to 14 nm; said drug poorly solublese classified as belonging to Class II or Class IV of the Biopharmaceutical Classification System, Elque the molecular weight of said poorly soluble drug is from about 200 to 1000, provided that this material substantially ordered mesoporous silica obtained in unabiomolécula absence of forming templates polyethylene glycol ester of alpha-tocopherol; wherein the liberacióninmediata means a release of at least 60% of the drug under physiological conditions (pH, temperature) within maximum 30 minutes to drug loads within a range dedesde about 5% to 40% in weight of a pharmaceutical composition comprendedicho poorly soluble drug loaded into said mesoporous silica material sustancialmenteordenado.