MicroRNA expression signature to predict survival and metastasis in hepatocellular carcinoma

摘要

A method for predicting survival of a subject with hepatocellular carcinoma (HCC), quecomprende measuring the level of a gene product of a miR in a test sample of subject tumoralesdel cells, wherein an alteration in the level of gene product miR in the test sample, relative withthe corresponding level of a miR gene product in a control free HCC tissue metastases esindicativa survival of the subject sample in which the miR gene product comprises: miR-30c [SEC . ID NO: 6], miR-124a [SEQ. ID NO: 4], miR-207 [SEQ. ID NO: 18] and miR-219 [SEQ. ID NO: 20], and wherein said alteracióncomprende increased expression levels of miR-219 [SEQ. ID NO: 20] and miR-207 [SEQ. ID NO: 18] and ladisminución levels of miR-30c [SEQ. ID NO: 6] and miR-124a [SEQ. ID NO: 4], which correlates with bajasupervivencia.