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Degeneration in vitro model of central nervous system and method of production thereof

机译：中枢神经系统的体外变性模型及其生产方法

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摘要

Degeneration in vitro model of central nervous system and method of production thereof. # The present invention relates to a method for obtaining an in vitro model in three dimensions of degeneration of the central nervous system (CNS). Furthermore, the present invention relates to an in vitro three-dimensional model of CNS degeneration obtainable by said method and the use of this model for the study of hydrocephalus. Finally, the present invention relates to a method of searching for neuroprotective drugs comprising culturing said in vitro model in three dimensions of CNS degeneration.

机译：中枢神经系统的体外变性模型及其生产方法。本发明涉及在中枢神经系统（CNS）变性的三个方面获得体外模型的方法。此外，本发明涉及可通过所述方法获得的CNS变性的体外三维模型以及该模型在脑积水研究中的用途。最后，本发明涉及一种搜索神经保护药物的方法，该方法包括在CNS变性的三个方面培养所述体外模型。

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公开/公告号ES2427718A1

专利类型
公开/公告日2013-10-31

原文格式PDF
申请/专利权人 SERVICIO ANDALUZ DE SALUD;UNIVERSIDAD DE MALAGA;
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申请/专利号ES20120030490
发明设计人 MATEOS GRONDONA JESUS;RUZ MALDONADO INMACULADA;DOMINGUEZ PINOS MARIA DOLORES;MARTINEZ LEON MARIA;FERNANDEZ-FIGARES PEREZ JOSE MANUEL;JIMENEZ LARA ANTONIO JESUS;
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申请日2012-03-30
分类号C12N5/079;
国家 ES
入库时间 2022-08-21 16:38:30

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Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - 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