CHIRAL LIGANDS, TRANSITION-METAL COMPLEXES THEREOF AND USES THEREOF IN ASYMMETRIC REACTIONS

摘要

Chiral ligands and transition metal complexes based on such chiral ligandsuseful in asymmetric catalysis are disclosed. The chiral ligands includephospholanes, P, N ligands, N, N ligands, biphenols, and chelating phosphines.The ferrocene-based irridium (R,R)-f-binaphane complex reduces imines to thecorresponding amines with 95-99.6 % enantioselectivity and reduces .beta.-substituted-.alpha.-arylenamides with 95 % enantioselectivity. The transitionmetal complexes of the chiral ligands are useful in asymmetric reactions suchas asymmetric hydrogenation of imines, asymmetric hydride transfer reactions,hydrosilylation, hydroboration, hydrovinylation, hydroformylation, allylicalkylation, cyclopropanation, Diels-Alder reaction, Heck reaction,isomerization, Aldol reaction, Michael addition and epoxidation reactions.