HYDROGELS OF HYALURONIC ACID AND ALPHA, BETA-POLYASPARTYLHYDRAZIDE AND THEIR BIOMEDICAL AND PHARMACEUTICAL USES

摘要

Compositions and products based on the chemical crosslinking of hyaluronicacid with a polyfunctional polymerhaving a protein-like structure, bearing hydrazido pendent groups along thepolymeric chain. The polymer is preferably,alpha-beta--polyaspartylhydrazide, a biocompatible macromolecule. Thematerials obtained after crosslinking, specifically hydrogels, undergoa reduced chemical and enzymatic degradation, unlike the starting hyaluronicacid, and they can be used to prepare systems forapplications in the biomedical and pharmaceutical field.