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DENDRIMERS COMPRISING TERMINAL PHARMACEUTICALLY ACTIVE AGENTS AND TERMINAL PHARMACOKINETIC MODIFYING AGENTS
DENDRIMERS COMPRISING TERMINAL PHARMACEUTICALLY ACTIVE AGENTS AND TERMINAL PHARMACOKINETIC MODIFYING AGENTS
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机译:包含末端药物活性剂和末端药代动力学修饰剂的树状物质
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摘要
The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described.
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