DYNAMIC OF SFLT-1 OR ENDOGLIN/PIGF RATIO AS AN INDICATOR FOR IMMINENT PREECLAMPSIA AND/OR HELLP SYNDROME

摘要

The mvention is concerned with diagnostic methods and tools. Specifically, the present invention relates to a method for diagnosing whether a pregnant subject is at risk for developing preeclampsia within a short period of time comprising: (a) determining the amounts of the biomarkers sFlt-1 or Endoglin and PIGF in a first and a second sample of said subject, wherein said first sample has been obtained prior to said second sample, (b) calculating a first ratio from said amounts of sFlt-1 or Endoglin and PIGF determined in the first sample and a second ratio from said amounts of sFlt-1 or Endoglin and PIGF determined in the second sample and (c) comparing the value of the said first and the said second ratio, whereby a subject being at risk for developing preeclampsia within a short period of time is diagnosed if the value of the second ratio is increased compared to the value of the first ratio by a factor of at least about 3. The present invention further relates to a method for differentiating between a pregnant subject being at risk of developing early-onset-preeclampsia and a pregnant subject being not at risk of developing early-onset-preeclampsia. Moreover, encompassed by the invention are devices and kits for carrying out these methods.