Methods of enhancing immune response using electroporation-assisted vaccination and boosting

摘要

Disclosed are methods of enhancing immune responses. Such methods involve theadministration of vaccine compositions to different tissues to elicit an enhancedimmune response. The enhanced response arises from the vaccination and boostingroute of administration in two separate patient tissues, for example, by firstadministering a priming vaccination into skin and later administering a boostvaccination in muscle. In each case, priming and boosting, the administrationof the vaccine composition is preferably carried out using contemporaneouselectroporation-assisted delivery of the antigenic agent.