Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells

摘要

The invention provides a method of determining an HCC subtype in a subject comprisinga) obtaining a sample from the subject, b) assaying the sample to detect the expressionof 1 or more biomarkers, and c) correlating the expression of the biomarkers withan HCC subtype in a subject. The invention further provides methods of detectingHCC stem cells in a sample. Additionally, the invention provides methods andcompositions for treating subjects with HCC that take advantage of the biomarkersassociated with HCC stem cells.