Method for the diagnosis of colorectal cancer and ovarian cancer by the measurement of vitamin E-related metabolites

摘要

The present invention relates to the diagnosis of colorectal and ovarian cancers (CRC and OC, respectively). The present invention describes the relationship between endogenous small molecules and CRC or OC. Particularly, the present invention relates to the diagnosis of CRC and OC through the measurement of the levels of specific metabolite markers. The present invention also relates to diagnostic markers identified in said method. The present invention relates to the underlying case and pre-symptomatic phases of CRC, the diagnosis of various stages and severity of CRC, the early detection of CRC, monitoring and diagnosing the effect of therapy on CRC and OC health states. - 64 - WO 2007/030928 rc1/cauuoluu1ou Serum samples from 40 CRC-positive and 60 normal individuals Sample extraction and analysis on FTMS CRC Comprehensive Normal Comprehensive Metabolic Profiles Metabolic Proles Identify metabolite differences (p0.05. Table 1) Setecion ofeptimal CRqiagnesti M4kerAs sing ppepvised mtoiyriatf araecross vaiae dase ae nAL Cete cross vaidated classifier ustig hlalf of ALL Sampos (C and n ormal) and apply predictor to the remaining blidedsape (untknown test poplation) 5 31 fS5 1/44T