DIAGNOSTIC METHOD FOR DETERMINING THE AGGRESSIVE AND PROGNOSIS OF PAPILLARY THYROID CANCER

摘要

This invention provides a diagnostic method that allows differentiating aggressive forms of PTC from non-aggressive PTC. The method involves the measurement of the CC3 expression in a thyroid FNA sample obtained from the patient that is under study. CCR3 can be measured by itself or in combination with other markers. The other makers that can be considered to determine prognosis of PTC correspond to the chemokine receptors CCR7 y CXCR4 and other any other available marker. An overexpression of CCR3 in a particular tumor correlates with its aggressive clinical parameters, such as capsule invasion and metastasis. The invention also refers to a kit to determine the prognosis of a PTC, which contains reagents for the detection of CCR3 in a thyroid tissue sample and usage instructions. In another embodiment of the invention a kit is provided to determine the prognosis of PTC, which includes reagents for the detection of PTC and other marker related to PTC. Other makers that can be quantified for the pronostic diasgnosis of PTC correspond to the chemokine CCR7, CXCR4 and/or other any other available marker.