STEM CELLS AND NEURAL CREST CELLS DERIVED FROM OLFACTORY ENSHEATHING GLIA, AND USES THEREOF

摘要

The invention relates to the production of stem cells and neural crest cells (neuron, glia and others) from the olfactory ensheathing glia (OEG, also called olfactory ensheathing cells or OEC), to the cells thus produced and to the uses thereof. More specifically, the invention relates to the stem cells and the precursors of the neural crest (or others) that are derived from the dedifferentiation of the olfactory ensheathing glia, that can be differentiated and give rise to different cell types, generally from the neural crest, but not necessarily. The invention also relates to the use of stem cells and the different cell lines obtained from the olfactory ensheathing glia, and the products derived from all the cell types produced, for treating illnesses; to cell therapy; to the search for, and design of, new medications; and to cellular, molecular, genomic and pharmacogenomic studies of human pathologies.