首页>
外国专利>
Adenoviral vectors expressing single chain interleukin-12 and 4-1BB ligand
Adenoviral vectors expressing single chain interleukin-12 and 4-1BB ligand
展开▼
机译:表达单链白介素12和4-1BB配体的腺病毒载体
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention relates to viral vectors comprising nucleic acid sequences coding for single chain interleukin-12 (single chain IL-12 or scIL12) and a costimulator protein, and to the use of vectors for gene therapy, especially for the treatment of tumors. The invention further relates to adenoviral vectors containing nucleic acid sequences having a sequence homology of at least 90% in relation to the sequence displayed in FIGS. 19 and 20 (IL-12), in FIG. 21 (4-1BB ligand) and in FIG. 22 (IL-2) and optionally also one of the sequences displayed in FIG. 23A (B7-1) or 23B (B7-2).
展开▼