RECOMBINANT ADENO-ASSOCIATED VIRUS-MEDIATED EXPRESSION OF FRACTALKINE FOR TREATMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE DISEASES

摘要

Methods are described pertaining to the use of fractalkine (FKN, CX3CL1 ) and its receptor CX3CRI for treatment of neuroinflammation and/or neurodegeneration. Also included are methods for treatment of neuroinflammation and/or neurodegenerative diseases, comprising: administering to cells of a subject in need of such treatment, an adeno-associated virus that comprises a functional fractalkine gene operably linked to transcriptional control elements. The methods are used to treat or ameliorate Parkinson's disease, neuroinflammatory and/or neurodegenerative diseases including, but not limited to, Alzheimer's disease, epilepsy, aging, and traumatic brain injury.