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KINETIC RESOLUTION OF CHIRAL AMINES

机译：手性胺的动力学解析

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摘要

The present invention refers to a method for the kinetic resolution of a chiral primary or secondary amine by treating the amine with a chiral, hydroxamic acid derived reagent of the formula (I). These chiral reagents are particularly useful for the kinetic resolution of cyclic amines and may be generated in situ in the presence of an N-heterocyclic carbene, thus allowing for a catalytic reaction.

机译：本发明涉及一种通过手性，异羟肟酸衍生的式（I）试剂处理胺来手性拆分手性伯或仲胺的方法。这些手性试剂对于环胺的动力学拆分特别有用，并且可以在 N -杂环卡宾的存在下原位生成，因此可以进行催化反应。 展开▼

著录项

公开/公告号WO2013007371A2

专利类型

公开/公告日2013-01-17

原文格式PDF

申请/专利权人 ETH ZURICH;BODE JEFFREY;BINANZER MICHAEL;
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申请/专利号WO2012EP02884

发明设计人 BODE JEFFREY;BINANZER MICHAEL;
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申请日2012-07-09

分类号C07D211/12;C07D217/02;C07D241/04;C07D265/30;C07D265/34;

国家 WO

入库时间 2022-08-21 16:35:32

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1. 一种手性胺的动力学拆分方法 [P] . 中国专利： CN102766672A . 2012-11-07

2. 一种手性磷酸催化喹啉‑3‑胺不对称转移氢化合成手性环外胺的方法 [P] . 中国专利： CN105001159B . 2017.11.21

3. KINETIC RESOLUTION OF CHIRAL AMINES [P] . 世界知识产权组织专利： WO2013007371A3 . 2013-10-03

机译：手性胺的动力学解析

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机译：手性2-和3-取代羧酸的动力学拆分

1. A Chiral Phosphorous Derivatizing Agent for the Determination of the Enantiomeric Excess of Chiral Alcohols, Amines by 31p NMR [J] . 中国化学快报（英文版） . 2001,第010期

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6. ACYLATIVE KINETIC RESOLUTION OF RACEMIC AMINES USING DERIVATIVES OF CHIRAL ACIDS(Abstracts) [C] . Victor P. Krasnov European Symposium on Organic Chemistry . 2007

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