首页> 外国专利> METHOD FOR THE DIRECT ELUTION OF REACTIVE 18F FLUORIDE FROM AN ANION EXCHANGE RESIN IN AN ORGANIC MEDIUM SUITABLE FOR RADIOLABELLING WITHOUT ANY EVAPORATION STEP BY THE USE OF STRONG ORGANIC BASES

METHOD FOR THE DIRECT ELUTION OF REACTIVE 18F FLUORIDE FROM AN ANION EXCHANGE RESIN IN AN ORGANIC MEDIUM SUITABLE FOR RADIOLABELLING WITHOUT ANY EVAPORATION STEP BY THE USE OF STRONG ORGANIC BASES

机译:直接从适合用于放射性标记的有机介质中的阴离子交换树脂中直接洗脱反应性18F氟化物的方法,无需使用强有机碱进行任何蒸发步骤

摘要

The present invention relates to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step characterised in that the eluting solution is a organic solution having a water content 3%, containing at least: an organic solvent suitable for the subsequent radiolabelling reaction; a first compound (A) which is a molecule containing at least one acidic hydrogen and a second compound (B) which is an organic base sufficiently strong to be able to tear off the acidic hydrogen of first compound (A) in an acid-base reaction leading to the formation of an organic salt (S).
机译:本发明涉及一种无需任何蒸发步骤就从水溶液中提取,浓缩和/或重新配制[18F]氟化物的方法,其特征在于,洗脱溶液是水含量<3%的有机溶液,其至少包含:适用于随后的放射性标记反应的有机溶剂;第一化合物(A)是包含至少一个酸性氢的分子,第二化合物(B)是有机碱,其强度足以使第一化合物(A)的酸性氢在酸碱中脱落反应导致形成有机盐(S)。

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