COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES OR DISEASES RELATED TO BONE MASS REDUCTION, CONTAINING 6-(3-HYDROXYPHENYL)-2-NAPHTHOL OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT

摘要

The present invention relates to a composition for preventing or treating inflammatory diseases or diseases related to bone mass reduction, containing 6-(3-hydroxyphenyl)-2-naphthol or a pharmaceutically acceptable salt thereof as an active ingredient. The 6-(3-hydroxyphenyl)-2-naphthol of the present invention inhibits the generation of proinflammatory cytokine in synoviocytes,reduces the rate of arthritis progression and the clinical disease index of arthritis in an animal model with arthritis, suppresses the loss and deformation of cartilage and bone, and alleviates the degree of inflammation of synovial tissue, the extent of bone erosion, the extent of chondrocyte destruction and the infiltration of immunocytes, and thus can be used as a composition for preventing or treating inflammatory diseases including arthritis. In addition, the 6-(3-hydroxyphenyl)-2-naphthol of the present invention inhibits the formation of osteoclasts, reduces bone resorption, suppresses the bone loss in an animal model with LPS-induced bone resorption, and improves trabecular bone volume, trabecular bone thickness, trabecular bone number, trabecular space area and the like in an ovariectomized animal model, and thus can be used as a composition for preventing or treating diseases related to bone mass reduction including osteoporosis.