USE OF MICROBUBBLE COMBINED WITH ULTRASONIC CAVITATION IN LIVER TRAUMA HEMOSTASIS

摘要

Provided is a hemostatic use of a microbubble combined with ultrasonic cavitation which is mainly used for hemostasis after bleeding following abdominal solid organ injury. Driven by a characteristic pulsed ultrasound, a microbubble ultrasound contrast agent in the circulation of blood produces ultrasonic cavitation with a certain intensity, destroys the blood capillaries in the local tissues, forms acute lesions around the bleeding blood vessels, hematoma and thrombus etc., compresses and blocks localized liver blood circulation, and succeeds in producing a hemostatic and therapeutic effect on the bleeding after liver trauma. The microbubble enters the human blood circulatory system by intravenous injection; the peak negative pressure of the pulse emitted by ultrasound is 1-9 MPa, and the pulse width is more than 20 cycles, with a low duty ratio and low sound intensity; the treatment produces high-intensity ultrasonic cavitation in the microvascular lumina of the liver, produces a strong non-thermal effect and mechanical damage effect, can result in pathological changes to the formation of microvascular rupture and damage, bleeding, hematoma and thrombus of the hepatic tissue, and turbidity and swelling of the hepatic tissues, etc., produces a temporary blocking effect of blood circulation of local tissue, and therefore further produces hemostatic and therapeutic effects.