首页> 外国专利> PHARMACEUTICAL COMPOSITION FOR INHIBITING THE TRANSCRIPTION FACTOR INDUCIBLE BY HYPOXIA, MODULATORS OF PATHOLOGICAL PROCESSES OF ANGIOGENESIS, ONCOGENESIS, INFLAMMATION, APOPTOSIS, AND CELLULAR THERAPY

PHARMACEUTICAL COMPOSITION FOR INHIBITING THE TRANSCRIPTION FACTOR INDUCIBLE BY HYPOXIA, MODULATORS OF PATHOLOGICAL PROCESSES OF ANGIOGENESIS, ONCOGENESIS, INFLAMMATION, APOPTOSIS, AND CELLULAR THERAPY

机译:抑制低氧诱导的转录因子,血管生成,致癌,炎症,凋亡和细胞治疗的病理过程调节剂的药物组合物

摘要

The present invention is included in the field of pharmacology and medical chemistry and relates to novel molecules represented by general formula (I), especially the one called FM19G11, as well as to pharmaceutical compositions containing them. Said pharmacologically optimized compositions are capable of modulating and/or inhibiting the transcription of genes modulated by the hypoxia-inducible transcription factor (HIF) and which are directly and/or indirectly involved in pathological processes related to cancer, inflammation, tissue repair, stem cell differentiation and regenerative therapy. The present invention also relates to a method for the synthesis of said molecules (I) and to the use thereof in the manufacture of a medicament for the treatment of the mentioned pathological processes.
机译:本发明包括在药理学和医学化学领域,并且涉及由通式(I)表示的新型分子,尤其是被称为FM19G11的分子,以及涉及包含它们的药物组合物。所述药理优化的组合物能够调节和/或抑制由缺氧诱导转录因子(HIF)调节的基因的转录,并且直接和/或间接地参与与癌症,炎症,组织修复,干细胞有关的病理过程。分化和再生疗法。本发明还涉及所述分子(I)的合成方法及其在制备用于治疗所述病理过程的药物中的用途。

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