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Pharmaceutical preparation containing Entacapone, Levodopa and Carbidopa
Pharmaceutical preparation containing Entacapone, Levodopa and Carbidopa
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机译:包含恩他卡朋,左旋多巴和卡比多巴的药物制剂
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摘要
Oral solid formulation comprises entacapone, levodopa and carbidopa and its salts or hydrates, and an excipient, where the levodopa and carbidopa in a first microtablet and the entacapone in a second microtablet are provided at a dose suitable for the treatment of Parkinson's disease. An independent claim is included for a process for producing the formulation comprising: (a) preparing levodopa and carbidopa containing aqueous granulation, in which granulation liquid components of the excipient are dissolved, and compressing the granules into microtablets, after drying and sieving the mixture; and (b) preparing a mixture of entacapone and a portion of the excipient, followed by dry compaction, and compressing the granules obtained in the dry compaction into microtablets. ACTIVITY : Antiparkinsonian. MECHANISM OF ACTION : Catechol-O-methyltransferase inhibitor.
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