SYNERGISTIC ANTI-CANCER ACTIVITY OF SR16388 WITH ANTI-MITOTIC DRUGS

摘要

The invention provides methods and compositions for inhibiting tumor growth in a mammal. The methods comprise administering to the mammal a synergistic combination of (E)-3-hydroxy-21-[2'-(N,N-dimethylamino)ethoxy]-19- norpregna- 1,3,5(10), 17(20)-tetraene and a microtubulin inhibitor like paclitaxel or vincristine. The combination of the compounds more than additively inhibits growth of tumor cells.