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RECOMBINANT STRAIN OF MYCOBACTERIUM BOVIS BACILLUS CALMETTE-GUERIN (BCG), IMMUNOGENIC COMPOSITION AND USE

机译：牛分枝杆菌的重组菌株卡介素-球蛋白（BCG），免疫原性组成和用途

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摘要

The present invention relates to recombinant strains of Mycobacterium that encode the mutated Escherichia coli LT heat-labile toxin or the A subunit of the mutated Escherichia coli LT heat-labile toxin. The present invention also relates to strains of Mycobacterium that encode the LT heat-labile toxin or the A subunit of the LT heat-labile toxin of Escherichia coli mutated in position 63. Specifically, the present invention relates to strains of Mycobacterium that encode the LT heat-labile toxin or the A subunit of the LT heat-labile toxin of Escherichia coli mutated in position 63 from serine to lysine. The present invention also provides immunogenic compositions that comprise the strains of the present invention. The present invention further provides for the use of said strains and immunological compositions in the production of a vaccine for preventing tuberculosis and infections caused by Mycobacterium tuberculosis. Lastly, the present invention relates to methods for preventing or treating tuberculosis in animals.

机译：本发明涉及编码突变的大肠杆菌 LT热不稳定毒素或突变的大肠杆菌的A亚基的分枝杆菌的重组菌株。 LT不耐热毒素。本发明还涉及编码在63位突变的大肠杆菌的LT热不稳定毒素或LT热不稳定毒素的A亚基的分枝杆菌菌株。具体而言，本发明涉及编码在63位突变的大肠杆菌的LT热不稳定毒素或LT热不稳定毒素的A亚基的分枝杆菌菌株。从丝氨酸到赖氨酸。本发明还提供了包含本发明菌株的免疫原性组合物。本发明进一步提供了所述菌株和免疫学组合物在制备疫苗中的用途，所述疫苗用于预防结核病和由结核分枝杆菌引起的感染。最后，本发明涉及预防或治疗动物结核病的方法。 展开▼

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公开/公告号WO2013120159A1

专利类型

公开/公告日2013-08-22

原文格式PDF

申请/专利权人 FUNDACAO BUTANTAN;DE CERQUEIRA LEITE LUCIANA CEZAR;PEREIRA NASCIMENTO IVAN;
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申请/专利号WO2013BR00049

发明设计人 DE CERQUEIRA LEITE LUCIANA CEZAR;PEREIRA NASCIMENTO IVAN;
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申请日2013-02-18

分类号C12N1/21;A61K39/04;A61K39/108;A61P31/06;C12R1/32;

国家 WO

入库时间 2022-08-21 16:31:22

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