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BOOSTING IMMUNE DEFENSE BY UPREGULATING CCAAT/ENHANCER BINDING PROTEIN EPSILON
BOOSTING IMMUNE DEFENSE BY UPREGULATING CCAAT/ENHANCER BINDING PROTEIN EPSILON
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机译:通过上调CCAAT /增强剂结合蛋白EPS来增强免疫防御能力
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摘要
The present invention demonstrates the important role of C/EBP in innate immune response against pathogens. Specifically, the inventors showed that in the absence of functional C/EBP, mice are severely impaired in their ability to clear S. aureus infection. Neutrophils are particularly affected, and susceptibility to S. aureus can be rectified by treatment with interferon-gamma (IFN-). Importantly, increased activity of C/EBP, either by induced overexpression of C/EBPE or by application of nicotinamide or an analog, derivative or salt thereof, dramatically enhances immune killing of S. aureus and leads to amelioration of infection.
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