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FVIIA-STF COMPLEXES EXHIBITING EXOSITE-MEDIATED SUPER ACTIVITY
FVIIA-STF COMPLEXES EXHIBITING EXOSITE-MEDIATED SUPER ACTIVITY
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机译:FVIIA-STF复合材料表现出异位介导的超级活性
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摘要
Disclosed are disulphide-linked complexes of a soluble Tissue Factor (sTF) variant of SEQ ID NO:3 comprising the mutation G109C and a Factor VIIa variant of SEQ ID NO. 1, comprising the mutation Q64C and a mutation at position M306 that gives rise to a zymogen-like conformation in the Factor VIIa polypeptide. Said complexes may be used for the treatment of a coagulopathy.
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机译:公开了包含突变G109C的SEQ ID NO:3的可溶性组织因子(sTF)变体和SEQ ID NO.7的VIIa因子变体的二硫键连接的复合物。在图1中,其包含突变Q64C和在位置M306的突变,该突变在因子VIIa多肽中引起酶原样构象。所述复合物可用于治疗凝血病。
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