SUSTAINED-RELEASE PREPARATION USING GASTRORETENTIVE DRUG DELIVERY SYSTEM

摘要

The present invention relates to a sustained-release preparation which limits release and absorption of drug using a gastroretentive system and which can minimize the effect of in vivo environment, and to a method for preparing the sustained-release preparation. More particularly, the sustained-release preparation according to the present invention comprises a swellable polymer, and a first controlled-release base and a second controlled-release base. Therefore, the sustained-release preparation of the present invention may adjust the degree of swelling and floating of a polymer in order to effectively achieve gastric retention. Thus, drugs may ultimately be retained in the gastrointestinal tract over a long period of time, and the bioavailability of drugs may be improved in order to enable once-a-day administration.