首页> 外国专利> Peptide vaccines with Seq Id No: 178, 174, 186 or 194 for cancers expressing tumor-associated antigens

Peptide vaccines with Seq Id No: 178, 174, 186 or 194 for cancers expressing tumor-associated antigens

机译:SEQ ID NO:178、174、186或194的肽疫苗,用于表达与肿瘤相关的抗原的癌症

摘要

The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: SEQ ID NO: 174, 178, 186, or 194 as well as peptides having the above-mentioned amino acid sequences in which 1, 2, or several (e.g., up to 5) amino acids are substituted, deleted, or added, provided the peptides possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with over-expression of the KIF20A, e.g. cancers containing as an active ingredient one or more of these peptides. The peptides of the present invention find further utility as vaccines.
机译:本发明提供了具有SEQ ID NO:SEQ ID NO:174、178、186或194所示氨基酸序列的肽,以及具有上述氨基酸序列的肽,其中1、2或多个(例如,最多5个)氨基酸被取代,缺失或添加,条件是该肽具有细胞毒性T细胞诱导性。本发明还提供了用于治疗或预防与KIF20A过度表达有关的疾病的药物,例如KIF20A。含有一种或多种这些肽作为有效成分的癌症。发现本发明的肽进一步用作疫苗。

著录项

  • 公开/公告号EP2594581A2

    专利类型

  • 公开/公告日2013-05-22

    原文格式PDF

  • 申请/专利权人 ONCOTHERAPY SCIENCE INC.;

    申请/专利号EP20120175484

  • 发明设计人 TSUNODA TAKUYA;OHSAWA RYUJI;

    申请日2008-02-21

  • 分类号C07K14/47;A61K39;A61P35;C07K14/745;C12N5/10;G01N33/15;G01N33/50;

  • 国家 EP

  • 入库时间 2022-08-21 16:29:39

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