首页> 外国专利> MANUFACTURING METHOD OF HIGH YIELD N-(O-(P-PIVALOYLOXYBENZENESULFONYLAMINO)BENZOYL)GLYCINE, AND LYOPHILIZED FORMULATION OF STABILIZED MONOSODIUM SALT*4 HYDRATE

MANUFACTURING METHOD OF HIGH YIELD N-(O-(P-PIVALOYLOXYBENZENESULFONYLAMINO)BENZOYL)GLYCINE, AND LYOPHILIZED FORMULATION OF STABILIZED MONOSODIUM SALT*4 HYDRATE

机译:高产N-(O-(对-邻苯二甲氧基苯甲磺酰氨基)苯甲酰基)甘氨酸的制备方法及稳定的铵盐* 4水合物的锂化配方

摘要

PURPOSE: A manufacturing method of lyophilized formulation is provided to enhance solubility and stability for long time.;CONSTITUTION: A manufacturing method of lyophilized formulation of stabilized monosodium salt*4 hydrate comprises the following steps: suspending a compound of chemical formula (I) in an aqueous solution; obtaining a homogeneous solution by controlling the pH of the suspended solution as 7.5-8.5 using sodium ethoxide; and manufacturing lyophilized formulation of tabilized monosodium salt *4 hydrate by lyophilizing the same solution at -50 deg. Celsius and pressure of 10 for 20 hours.;COPYRIGHT KIPO 2013
机译:目的:提供一种冻干制剂的制备方法,以提高其长时间的溶解性和稳定性。组成:稳定化钠盐* 4水合物冻干制剂的制备方法包括以下步骤:将化学式(I)的化合物悬浮于水溶液用乙醇钠将悬浮液的pH控制在7.5-8.5,得到均匀的溶液。通过在-50℃下冻干相同的溶液,制得塔状单钠盐* 4水合物的冻干制剂。摄氏10度和20个小时的压力。; COPYRIGHT KIPO 2013

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