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VECTOR CONTAINING LOW DENSITY LIPOPROTEIN-LIKE CATIONIC NANOPARTICLES FOR DELIVERING A BLOOD-BRAIN BARRIER
VECTOR CONTAINING LOW DENSITY LIPOPROTEIN-LIKE CATIONIC NANOPARTICLES FOR DELIVERING A BLOOD-BRAIN BARRIER
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机译:包含低密度脂蛋白样阳离子纳米颗粒的载体,可释放血脑屏障
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摘要
PURPOSE: A vector for delivering a BBB(blood brain barrier) is provided to deliver a nucleic acid drug to a target cell, and to be used in a pharmaceutical composition for preventing or treating brain diseases.;CONSTITUTION: A vector containing LDL-like cationic nanopaticles for delivering a BBB comprises: a core lipid part containing cholesteryl ester and triglyceride; and a cationic surface lipid part which is conjugated on the upper layer of the core lipid part by hydrophobic interaction, and contains phospholipid and cationic lipid without cholesterol and ApoE. The surface lipid part does not contain apolipoprotein. The nanoparticles contain 30-60wt% of cholesteryl ester, 0.1-10 wt% of triglyceride, 5-20wt% of cholesterol, 5-30wt% of phospholipid, and 10-50wt% of cationic lipid. The core lipid part and the surface lipid part are mixed in a weight ratio of 30:70-70:30.;COPYRIGHT KIPO 2013
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