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SYNTHESIZING METHOD OF A BENZOYLOXY BENZOPHENONE COMPOUND WITH AN INFLAMMATION FUNCTION GUIDED TO PROSTAGLANDIN H SYNTHASE, IN HUMAN BODY, BY USING A SITE-SELECTIVE FRIES TRANSITION REACTION
SYNTHESIZING METHOD OF A BENZOYLOXY BENZOPHENONE COMPOUND WITH AN INFLAMMATION FUNCTION GUIDED TO PROSTAGLANDIN H SYNTHASE, IN HUMAN BODY, BY USING A SITE-SELECTIVE FRIES TRANSITION REACTION
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机译:人体选择性前列腺素H合成酶诱导发炎功能的苯氧苯甲酮类化合物的合成方法
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摘要
PURPOSE: A manufacturing method of a benzoyloxy benzophenone compound is provided to selectively obtain an only ortho-isomer while changing temperature, various Lewis acid and solvent in reaction of Fries rearrangement.;CONSTITUTION: A manufacturing method of a benzoyloxy benzophenone compound comprises a step of synthesizing 4-substitued benzoic acid represented by chemical formula 1 and benzoyloxy benzophenone represented by chemical formula 6, through an orthohydroxybenzophenone, as an intermediate compound, represented by chemical formula 4, synthesized by Fries rearrangement reaction represented by chemical formula 3. In the chemical formulas, R1, R2, and R3 is selected from alkyl or halogen, the alkyl can be alkyl or cycloalkyl, and the halogen can be fluorine, chlorine, bromine, or iodine.;COPYRIGHT KIPO 2013
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