MANUFACTURING METHOD OF AN ORGANIC FLUOROCOMPOUND LABELED WITH A RADIOACTIVE ISOTOPE, FLUORINE-18, FOR INCREASING A REACTION RATE BY USING GLYCOLE AS A CATALYST IN PRESENCE OF A POLAR APROTIC SOLVENT IN LABELING REACTION

摘要

PURPOSE: A manufacturing method of an organic [18F]fluoro-compound is provided to obtain a compound labeled with a 18-fluoride at high purity and high yield by increasing a reaction rate and suppressing the sub-reactions by using glycol as a catalyst.;CONSTITUTION: A manufacturing method of an organic [18F]fluoro-compound comprises preparing an organic fluoro compound labeled with fluorine-18 by reacting an alkyl sulfonate and a [18F]fluoride salt in a reaction solvent, wherein glycol represented by formula 1 is used as a catalyst. In formula 1, R^1, R^2, R^3, and R^4 are each independently a hydrogen atom or a C1-C10 alkyl group. The [18F]fluoride salt is a metal-[18F]fluoride salt or an ammonium-[18F]fluoride salt. The reaction solvent is a polar aprotic solvent or a polar protic solvent.;COPYRIGHT KIPO 2013;[Reference numerals] (AA) Suppress nucleophilicity removal reaction (E2); (BB) Reaction speed of nucleophilicity removal reaction (S_N2) : Rapid