BIODEGRADABLE DIBLOCK COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES AND METHODS OF USE THEREOF

摘要

biodegradability of 61 to 85 wt% , which includes a polyester biodegradable, hydrophobic A block and a 5000 dalton number average molecular weight of less than (number average molecular weight) of a biocompatible 15 to 39 wt% , including polyethylene glycol (PEG) having a single functional group to hold , the water-soluble B block comprising a hydrophilic , biodegradable AB type diblock the polymers are suggested , wherein the diblock copolymer has a number average molecular weight of less than 15,000 retention and shows a reversible thermal gelation properties .