Novel inden derivatives substituted with alkyl group containing pyridine, pharmaceutically acceptable salts or isomer thereof, process for the preparation thereof and pharmaceutical composition for prevention or treatment of PAR-1 related diseases containing the same as an active ingredient

摘要

The present invention relates to an indene derivative, a pharmaceutically acceptable salt thereof, or an isomer, their preparation and pharmaceutical compositions for the treatment of PAR-1 related diseases comprising the same substituted by comprising the novel pyridine alkyl will. Indene derivatives of the present invention exhibits the excellent a PAR-1 antagonist effect, as prophylactic or therapeutic pharmaceutical composition, antagonist for the PAR-1 related diseases, coronary artery disease, vein thrombosis, cerebrovascular disease or arteriosclerosis, vascular re- obstruction, blood clotting, can be used in high blood pressure, arrhythmia, thrombosis-related diseases including cardiovascular diseases, including angina pectoris, heart failure, inflammation, or preventing or treating cancer.