Method for predicting susceptibility to cardiovascular disease using SNP of klotho genes

摘要

PURPOSE: A cardiovascular disease prediction method using the single nucleotide polymorphism of Klotho gene is provided to be practically used for the prevention and the early diagnosis of the cardio vascular disease as it verifies genetic factors which causes cardiovascular disease. CONSTITUTION: A marker for prediction of the degree of the cardiovascular disease outbreak danger is selected from rs3631726 with the base rank in a rank number 3 and composed of a polynucleotide or a supplementary polynucleotide thereof with 20-100 continuous DNA rank in which 27th base (744th base from the transcription starting point of the klotho gene) is A or lacked. The cardiovascular disease is selected from the myocardial infarction, angina, atherosclerosis, hypertension, cardiac failure, blood tumor, artery scleroma, embolism, stroke and thrombosis. A probe or a primer is included which can detect the cardiovascular disease pathogenic risk marker for prediction. The kit is the RT-PCR kit or the DNA chip kit. Polynucleotide or its supplementary polynucleotide with 20-100 of continuous DNA rank is included that is selected from rs36217263 with the base rank of the rank number 3 and in which 27th base (744th base from the transcription starting point of the klotho gene) is A or lacked.