Preparation of biocompatible polymeric drug delivery system with advanced tumor accumulation

摘要

PURPOSE: A biocompatible polymer delivery system for drug delivery with the surface modified by glycol chitosan and heparin is provided to enhance blood retention and circulation and to effectively deliver a drug to a target site of cancer tissue. CONSTITUTION: A method for preparing biocompatible polymer nano delivery system comprises: a step of mixing and dissolving polyoxyethylene sorbitan monooleate(Tween80) of chemical formula 1 with drug; a step of adding lecithin lipid of chemical formula 2 to the mixture and mixing; a step of impregnating the secondary mixture to a triblock copolymer solution of chemical formula 3(HO(C_2H_4O)_a(C_3H_6O)_b(C_2H_4O)_cH) to prepare a nano delivery system; and a step of adding glycol chitosan of chemical formula 4 and heparin solution of chemical formula 5 to the nano delivery system to modifier the surface of the nano delivery system.