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Pharmaceutical Composition for Preventing and/or Treating of Corneal Dystrophy Associated with TGFBI Gene Mutation and Its Screening Method

机译：预防和/或治疗与tgfbi基因突变相关的角膜营养不良的药物组合物及其筛选方法

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摘要

The present invention relates to a pharmaceutical composition comprising TGFBI The present invention relates to a pharmaceutical composition for preventing or treating genetically modified corneal dystrophy and a screening method thereof. Since the composition of the present invention effectively decomposes and removes only mutant TGFBI proteins without affecting TGFBI proteins in normal cells, TGFBI It is very effective in preventing and treating corneal abnormalities caused by genetic variation. In addition, the screening method of the present invention is TGFBI in addition to the composition It provides a simple and efficient way to identify new substances that are effective in preventing or treating genetically modified corneal dystrophy.

机译：本发明涉及包含 TGFBI 的药物组合物。本发明涉及用于预防或治疗基因修饰的角膜营养不良的药物组合物及其筛选方法。由于本发明的组合物有效地分解和去除了突变的TGFBI蛋白而不会影响正常细胞中的TGFBI蛋白，因此 TGFBI 对于预防和治疗由遗传变异引起的角膜异常非常有效。另外，本发明的筛选方法是除组合物外的 TGFBI。它提供了一种简单有效的方法来鉴定对预防或治疗基因改造的角膜营养不良有效的新物质。 展开▼

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公开/公告号KR101320943B1

专利类型

公开/公告日2013-10-23

原文格式PDF

申请/专利权人
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申请/专利号KR20100036479

发明设计人 김응권;최승일;
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申请日2010-04-20

分类号A61K31/436;A61P27/02;A61P27;

国家 KR

入库时间 2022-08-21 16:24:18

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