METHOD FOR IDENTIFICATION AND SELECTION OF MEDICINE CANDIDATES FOR COMBINED PHARMACEUTICAL PRODUCTS

摘要

1. A method for identifying and selecting chemical compounds having or providing a functional effect to provide a mixture containing at least 2 chemical compounds with a desired functional effect, said method comprising the steps of:! a) providing n samples, each of which contains a chemical compound to be analyzed; ! b) mixing 2 or more of these n samples in all possible combinations to obtain the first set of mixtures to be analyzed; ! c) subjecting said first set of mixtures to a functional analysis allowing the measurement of a functional parameter in order to identify chemical compounds that contribute to the functional effect; ! d) sampling m samples, each of which contains a chemical compound that promotes the functional effect in step c), where m is less than n; ! e) mixing two or more of these m samples in all possible combinations to obtain a second set of samples to be analyzed; ! f) subjecting said second set of mixtures to a functional analysis allowing the measurement of a functional parameter in order to identify chemical compounds that contribute to the functional effect; and! g) selection of a mixture with the desired functional effect. ! 2. The method according to claim 1, where stages d, e and f are repeated for individual subgroups, each of which contains m selected samples. ! 3. The method according to claim 2, where stages d, e and f are repeated 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 times, and where the stages are reproduced in parallel or sequentially. ! 4. The method according to claim 1, where a mixture containing 3 chemical compounds is detected and selected, mixing 3 of these n samples in step b. !5. The method according to claim 2, where detect and