DERIVATED CONDENSING RING STRUCTURE DERIVATIVE AND ITS APPLICATION IN MEDICINE

摘要

1. A derivative containing a condensed ring structure represented by the formula (I): wherein X and X are independently CH or N; the ring U is Caryl or a 5- or 6-membered heteroaryl; m is an integer from 0 to 2 ; n is an integer from 0 to 3; R is a hydroxy group, a halogen atom, amino or C 1-6 alkyl, and when m is 2, the two Rs are optionally different from each other; R is any of (1) - (11) :( 1) a halogen atom; (2) a hydroxy group; (3) cyano; (4) n tro; (5) carboxy; (6) carbamoyl; (7) amino; (8) C1-6alkyl, C1-6 alkenyl or C1-4 alkoxy, each of which may independently contain any group selected from the substituent group α; (9) C1-6 alkynyl, C1-4 alkylsulfonyl, mono di) Calkylsulfamoyl, Cacyl, Calkoxycarbonyl, Calkoxycarbonyloxy, mono (di) Calkylamino, mono (di) Calkoxy Calkylamino, Calkoxy Calkyl (Calkyl) amino, Cacylamino, Calkoxycarbonylamino, Calkoxycarbono (di) Calkoxy C 1-6 alkylcarbamoyl, C 1-4 alkoxy C 1-6 alkyl (C 1-6 alkyl) carbamoyl, mono (di) C 1-6 alkylaminocarbonylamino, C 1-6 alkylsulfone lamino or C1-6alkylthio; (10) Cycloalkyl, 3-8 membered heterocycloalkyl, Cycloalkenyl or 5-8 membered heterocycloalkenyl; (11) Saryl, Saryloxy, Sarylcarbonyl, 5 or 6 membered heteroaryl, 5- or 6 membered heteroaryloxy, 5 - or a 6-membered heteroarylcarbonyl, Sarylamino, Saryl (C1-6alkyl) amino, 5- or 6-membered heteroarylamino, or a 5- or 6-membered heteroaryl (C1-6alkyl) amino; and when n is 2 or 3, these R are optionally different from each other, and when there are two R linked to adjacent atoms and independently are C 1-6 alkyl or C 1 alkoxy, which