METHOD FOR PRODUCING IODIZED CONTRAST AGENT

摘要

1. A method of obtaining a compound of formula (VII) by the condensation reaction of a compound of formula (V) and an amino alcohol of formula (VI), moreover, this reaction is carried out in an aprotic dipolar organic solvent in the presence of an oxide or hydroxide of an alkaline or alkaline earth metal oxide R - a linear or branched alkyl group, containing from 1 to 6 carbon atoms, optionally substituted with one or more hydroxyl substituents, optionally in a protected form, and this alkyl group may be interrupted by one or more heteroatoms selected from —O— and —NH—; R is a hydrogen atom or an R group; R is a linear or branched alkyl group containing from 1 to 4 carbon atoms substituted with at least one hydroxyl group; R is a hydrogen atom or group R.2. The method according to claim 1, wherein the alkali or alkaline earth metal hydroxide is selected from sodium or calcium hydroxide. The method of claim 2, wherein the hydroxide is calcium hydroxide. The method according to claim 1, wherein the alkali or alkaline earth metal oxide is selected from magnesium oxide or calcium. The method according to any one of the preceding paragraphs, wherein: R is —CH; R— —OCOCH; and R, R- —CH (CHOH). 6. The method according to claim 1, characterized in that the compound of formula (V), in which R is —COCH and R is —CH, is prepared by reacting 5-amino-2,4,6-triiodoisophthalic acid dichloride (I) with dichloride (S) ) - [2- (acetyloxy)] propionic acid in an aprotic dipolar organic solvent. 7. A method according to any one of claims 1 to 4 and 6, wherein the aprotic dipolar organic solvent is dimethylacetamide (DMA). The method according to any one of claims 1 to 4, in which: R is -CH; R- -OCOCH; and R, R- —CH (CHOH), and in